Vaccination reduces the risk of severe COVID-19 infection

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However, frail adults, who live in areas with high deprivation or who have unhealthy lifestyles, have a higher risk of COVID-19 infection and getting sick, despite being vaccinated, compared to other vaccinated people.

Researchers at King’s College London analyzed data from participants who recorded their symptoms, tests and vaccines in the UK’s ZOE COVID Symptom Study app between 8 December 2020 and 14 May 2021, including 1,102. 192 people who had been vaccinated. They examined in detail 2,278 adults who tested positive for COVID-19 after vaccination and compared them with vaccinated adults who tested negative for COVID-19 and unvaccinated adults who tested positive for COVID-19. The team focused on infections that developed more than 14 days after receiving a dose of the Pfizer or AstraZeneca vaccine, which is when immunity begins to develop according to the results obtained in a previous study published in The Lancet.

He prepress study fewer milder symptoms were reported in vaccinated individuals compared with unvaccinated adults who had contracted the virus, and those who had had a sting were more likely to be completely asymptomatic. Only 104 people were hospitalized in the vaccinated group, compared with 239 in the unvaccinated group. People over the age of 60 have a higher risk of long-term COVID, but the analysis showed that the risk of prolonged symptoms decreased by 28% in the unlikely event of long-term COVID. after a vaccine. This suggests that the risk of long-term COVID is substantially lower if an elderly person is vaccinated.

The nature of the symptoms was similar to that of unvaccinated adults (e.g., anemia, cough, fever, headache, and fatigue), but all of these symptoms were milder and were reported less frequently by vaccinated individuals and had the half the chances of presenting multiple symptoms in the first week of illness. Sneezing was the only thing which was reported more frequently in people vaccinated with COVID-19.

However, the individuals they had which limited their independence, such as fragility, had a higher risk of COVID-19 infection after vaccination and disease. Age alone, however, was not a risk factor. Adults living in areas with higher deprivations were constantly at higher risk of infection despite vaccination, even when they adapted to health behaviors. COVID-19 infection in vaccinated individuals was less likely in individuals with a healthy lifestyle, e.g., a healthy diet and a normal body mass index.

The results demonstrate the need for a policy aimed at risk groups. Fragile in residential settings they have already been shown to be disproportionately affected by COVID-19. The research team suggests strategies such as a timely reinforcement program, specific infection control measures, and more research on the immune response to vaccination in this group that can help address the problem.

Professor Sebastien Ourselin, head of school at the School of Biomedical Engineering and Imaging Sciences, said: “Without such broad and daily access to a diverse population through the application, it would have been very demonstrated. difficult to identify so quickly those groups of individuals most at risk of COVID-19 infection after vaccination.This work is further demonstration that the combination of massive data, digital technology and citizen science can change the way we approach the major public health challenges “.

Professor Tim Spector, senior scientist at the ZOE COVID Symptom Study app and professor of genetic epidemiology at King’s College London, said: “This research shows the value of the millions of people who continue to report their symptoms to the app. COVID Symptoms Study to help understand how to better protect our populations as we move into the post-vaccination era. ”


A real-world study shows the power of Pfizer, Modern vaccines to prevent COVID


More information:
Michela Antonelli et al, Post-vaccination infection SARS-CoV-2: risk factors and disease profile in a case-control study based on the observational, prospective community medRxiv (2021). DOI: 10.1101 / 2021.05.24.21257738

Citation: Vaccination Reduces Risk of Serious COVID-19 Infection (2021, June 11) Retrieved June 11, 2021 at https://medicalxpress.com/news/2021-06-vaccination-severe-covid- infection.html

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