New findings published in JAMA Neurology suggest that there are no differences in cognitive outcomes at the age of 2 years between children of healthy women and children of women with epilepsy who took unsportsmanlike medications during pregnancy. The findings are part of the large research project Maternal Outcomes and Effects of Neurodevelopment of Antiepileptic Drugs (MONEAD), which is a long-term prospective study that analyzes outcomes in pregnant women with epilepsy and their children. The study was funded by the National Institute of Neurological Disorders and Disorders (NINDS), which is part of the National Institutes of Health.
This study reports results from 382 children (292 children born to women with epilepsy and 90 born to healthy women) who were assessed for language development at the age of 2 years. The researchers also compared development scores with blood levels of unsportsmanlike drugs in the third trimester.
The results suggest that children born to healthy women and those born to women with epilepsy show no significant differences in language development scores at the age of 2 years. language development related to third-trimester blood levels of epilepsy medications. Most women with epilepsy in the study were taking lamotrigine and / or levetiracetam.
However, the study found that those children born to mothers with the highest levels of unsportsmanlike medications in the blood during the third trimester had slightly lower scores on the motor and general adaptive domain tests, which refer to related skills. with self-care, such as food.
Children in this study will continue to follow each other and participate in additional cognitive tests until age 6. The results indicated so far indicate that controlling epilepsy with these medications during pregnancy may be safe for babies.
Kimford J. Meador et al, two-year cognitive outcomes in children of pregnant women with epilepsy in maternal outcomes and effects of neurological development of antiepileptic drugs, JAMA Neurology (2021). DOI: 10.1001 / jamaneurol.2021.1583
National Institutes of Health
Citation: The study suggests that there is no link between unsportsmanlike drugs used during pregnancy and cognitive problems in infants (2021, June 7), retrieved June 8, 2021 at https://medicalxpress.com/ news / 2021-06-link-antiseizure-drugs-pregnancy-cognitive .html
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