The study reveals how Y-cell binding protein 1 promotes cancer metastasis

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YB1 triggers cell invasion and cancer metastasis by regulating the miRNA200 / 205b-ZEB axis. Credits: LIU Xiumei and CHEN Di

Cancer metastasis is the leading cause of cancer death, as well as the leading challenge in cancer treatment.

Recently, a group led by Professor Piao Hailong of the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy of Sciences (CAS) revealed that the binding protein 1 to the Y box of the binding protein to nucleotides (YB1) can promote liver metastasis by regulating microRNA (miRNA) biosynthesis.

This study was published in Communications against cancer on June 10th.

The researchers found that YB1 could significantly inhibit the biosynthesis and expression of miRNA-200b and miRNA-205 by interacting with the microprocessor complex of DRCR8, Dicer, and TUTs of the terminal UTP transferase. He then regulated the expression of the homeobox 1 (ZEB1) bond binding the E-box with zinc fingers. for cancer metastasis.

The development of lung cancer metastasis was simulated by a injected through the tail vein and the researchers found that YB1 could promote lung metastasis of hepatocellular carcinoma cells.

In addition, transcriptomic data from clinical tissues showed that YB1 expression was positively correlated with ZEB1 in liver cancer tissues and negatively correlated with miRNA200 and miRNA205b expression. The miRNA200 / 205b-ZEB1 signaling pathway correlated significantly with patient prognosis.


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More information:
Xiumei Liu et al, YB1 regulates the miR-205 / 200b‐ ZEB1 axis by inhibiting microRNA maturation in hepatocellular carcinoma, Communications against cancer (2021). DOI: 10.1002 / cac2.12164

Citation: Study Reveals How Y-Box Binding Protein 1 Promotes Cancer Metastasis (2021, June 11) Retrieved June 11, 2021 at https://medicalxpress.com/news/2021-06 -reveals-y-box-protein-cancer-metastasis. html

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