A team of researchers led by Rutgers has developed a microchip that measures stress hormones in real time from a drop of blood.
The study appears in the journal Scientific advances.
Cortisol and others stress hormones regulate many aspects of our physical and mental health, including sleep quality. High cortisol levels can cause poor sleep, which increases stress which can contribute to panic attacks, heart attacks and other illnesses.
Currently, measuring cortisol requires expensive and heavy laboratory configurations, so the Rutgers-led team looked for a way to control their natural fluctuations in daily life and provide patients with feedback that will allow them to receive the right treatment at the right time.
The researchers used the same technologies used to manufacture computer chips to create sensors thinner than human hair that can detect biomolecules at low levels. They validated the performance of the miniaturized device in 65 blood samples from patients with rheumatoid arthritis.
“The use of nanosensors allowed us to detect cortisol molecules directly without the need for any other molecules or particles to act as labels,” said lead author Reza Mahmoodi, a postdoctoral fellow in the Department of Electrical and Computer Engineering at Rutgers-New Brunswick University.
With technologies like the team’s new microchip, patients can control their hormone levels and control them better. chronic inflammation, stress and other conditions at a lower cost, said lead author Mehdi Javanmard, an associate professor in Rutgers ’Department of Electrical and Computer Engineering.
“Our new sensor produces an accurate and reliable response that allows a continuous reading of cortisol levels for real-time analysis,” he added. “It has great potential to adapt to non – invasive people cortisol measured in other fluids such as saliva and urine. The fact that no molecular labels are required eliminates the need for large bulky instruments such as optical microscopes and plate readers, making reading instrumentation something you can measure in a small box or even fit in a bracelet one day “.
“Single-step unlabeled nanowell immunoassay accurately quantifies serum stress hormones in minutes” Scientific advances (2021). avances.sciencemag.org/lookup … .1126 / sciadv.abf4401
Citation: New microchip sensor measures blood drop stress hormones (2021, June 30) retrieved July 1, 2021 at https://medicalxpress.com/news/2021-06-microchip-sensor -stress-hormones-blood.html
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