Not all kidney cancers behave the same way, with very different responses to immunotherapy or other treatments, and the results are very different for patients.
By sequencing the RNA of individual cells within multiple benign and cancerous kidney tumors, researchers at the Rogel Cancer Center at the University of Michigan have identified cells where different subtypes originate, the pathways involved, and how tumor microenvironment affects the development of cancer and the response to treatment.
“Single – cell RNA sequencing was key to allowing us to control patterns of gene expression in each individual cell, revealing the mechanisms at play within the tumor microenvironment that can predict overall survival, ”says study author Arul Chinnaiyan, MD, Ph.D., director of the Michigan Center for Translational Pathology and SP Hicks Professor of Pathology at Michigan Medicine.
The researchers generated atlases of gene expression from normal samples of renal and renal cell carcinoma. They predicted the supposed source cell of more than 10 subtypes of kidney cell cancer. The analysis also revealed pathways and interactions within the tumor microenvironment that predicted whether the tumor would respond to immunotherapy. This could lead to biomarkers to help guide kidney cancer treatment.
“Understanding the cell type where a cancer originates can allow us to target more precise treatments for that type of cancer and better understand the response to therapy,” Chinnaiyan says.
Yuping Zhang et al., “Monocellular analyzes of kidney cell cancer reveal information about the tumor microenvironment, the source cell, and the response to therapy.” PNAS (2021). www.pnas.org/cgi/doi/10.1073/pnas.2103240118
University of Michigan
Citation: The analysis reveals how kidney cancer develops and how it responds to treatment (2021, June 7) retrieved June 7, 2021 at https://medicalxpress.com/news/2021-06-analysis-reveals- kidney-cancer-treatment.html
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