Testosterone therapy reduces heart attack and stroke

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Testosterone supplementation significantly reduces heart attacks and strokes in men with abnormally low hormone levels, according to new research presented today at the European Urology Association congress.

The ten-year study included more than 800 testosterone-deficient men from Germany and Qatar, whose family history was: , , diabetes or weight are at high risk for them or .

Only men with below normal, who also showed symptoms of low testosterone, such as low mood, decreased appetite, depression, erectile dysfunction, loss of libido, or weight gain.

Just over half of men opted for long-term testosterone replacement therapy, which allowed researchers to compare this group with those who did not treat their condition. All men were encouraged to make lifestyle changes, in terms of diet, alcohol, smoking and exercise, to improve their cardiovascular health.

Of 412 men on testosterone therapy, 16 died and none suffered stroke attack. Of the 393 men who chose not to take testosterone supplements, 74 died, 70 had a heart attack and 59 suffered a stroke. Even when the age discrepancy was taken into account (the group taking testosterone was on average five years younger than the other group), these differences remained clearly small. For men under 55, the risk of heart attack and stroke was reduced by 25 percent; for men over 60, the risk was reduced by 15 percent.

The health of men on testosterone therapy also improved with other measures. They lost weight, had more lean muscle mass, improved their cholesterol level and liver function, better controlled diabetes and lowered blood pressure.

Professor Omar Aboumarzouk, of Hamad Medical Corporation in Qatar, explains: “Since all these men would normally have been expected to suffer a heart attack or stroke in the next five or ten years, without any other intervention, it was a real surprise for not seeing any cardiovascular events in the group on testosterone therapy.

However, the team wants to emphasize that testosterone therapy is not a silver bullet and should only be considered for patients who meet certain criteria.

“Testosterone can be seriously harmful if taken by men with , or they work perfectly with low hormone levels, “says Professor Aboumarzouk.” While men need testosterone for certain psychological and biological functions, it is likely that only those with low levels who exhibit other symptoms will benefit from testosterone therapy.

“For those at high risk for heart attack and stroke, with testosterone deficiency, it is likely that the return of the hormone to normal levels will help them maximize the benefits of other steps needed to improve their health. This includes increasing exercise levels, eating healthier foods, quitting smoking, and reducing alcohol consumption.

“We believe that physicians treating patients with low testosterone, who are at high risk for heart attack or stroke, should consider testosterone therapy as one aspect of their treatment.”

The study, involving researchers from Dresden, Bremen and Münster in Germany, and Doha in Qatar, is still ongoing.

Dr. Maarten Albersen, a member of the UAU Scientific Office at the University of Leuven in Belgium, says: “The long-term cardiovascular risks or benefits of testosterone therapy are not yet clear, due to the contradictory results from previous research.This new study has shown a reduction in major cardiovascular events and mortality in men who received testosterone therapy, compared with men who chose not to receive this treatment.

“However, these were men with a medium risk of heart attack or stroke, and those receiving testosterone were younger and had a slightly lower risk at the start of the study. The study was sufficient. long to see differences in the rate of cardiovascular events.However, the figures involved and the fact that the trial has not been done at random means that it is still difficult to draw difficult conclusions.New trial is now underway with the goal of recruiting 6,000 participants, which should provide definitive answers about cardiovascular risks or even hormone benefits in men with low . ”


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Citation: Testosterone Therapy Reduces Heart Attack and Stroke (2021, July 10) Retrieved July 10, 2021 at https://medicalxpress.com/news/2021-07-testosterone-therapy-heart.html

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