Researchers have discovered a new mechanism regulating the regenerative capacity of the skin hair


Proposed miR-24 model that limits the regenerative competence of HF parents. Credit: Professor ZHANG Liang’s group

Statistics from the National Health Commission of the People’s Republic of China show that the number of Chinese with alopecia or hair loss has increased sharply in recent years and exceeded 250 million. However, effective treatment for this disease is still lacking.

On the skin, activation of follicle stem cells (HFSCs) and progenitors by stimulating growth factor are the basis for HF and hair regeneration. On the other hand, hair regeneration defects are often attributed to blunt HF responses to growth stimuli. However, it is not yet well understood how the sensitivity of HFSCs or parents to growth stimuli is determined. Clarifying this question will provide important clues for treating hair-related diseases, such as alopecia.

In a study published in Cell reports, Professor Zhang Liang’s group of the Shanghai Institute of Nutrition and Health (SINH) of the Chinese Academy of Sciences and collaborators revealed the role of miR-24 and its mechanism in limiting competition regeneration of hair follicle (CI) progenitors, illuminating a new therapeutic route for the treatment .

The researchers found that the transition from rest to HF activation is associated with significant downregulation of a microRNA, miR-24, in HF progenitors prior to activation.

In constructing and analyzing mouse models, they found that miR-24 acts to limit the sensitivity of HF progenitors to growth stimuli. Overexpression of miR-24 in the skin epithelium significantly delayed HF progenitor activation and hair cycle progression, while its conditional ablation significantly accelerated the hair cycle and sharpened sensitivity. from HF to growth stimuli.

It is worth noting that conditional ablation of miR-24 in the skin epithelium significantly improved the effect of the Minoxidil lotion on hair growth stimulation without discernible side effects, indicating miR-24 as a potential new target for hair regeneration therapies.

Mechanically, the researchers found that Plk3 is a new miR-24 target gene that mediates miR-24 function to limit hair growth by regulating CCNE1, a key regulator of the cell cycle. They also found that miR-24 acts on the low bone morphogenetic protein (BMP), which is a known inhibitory signal for hair growth.

The results of this study revealed that miR-24 is a key factor limiting the regenerative competition of skin HF. .

How (SC) respond appropriately to it is a matter of fundamental importance in the biology of SC.

The bald truth: altered cell divisions cause hair thinning

More information:
Fengzhen Liu et al, miR-24 controls the regenerative competition of hair follicle progenitors by targeting Plk3, Cell reports (2021). DOI: 10.1016 / j.celrep.2021.109225

CitationResearchers discovered a new mechanism regulating the regenerative capacity of skin hair (2021, June 11) recovered on June 12, 2021 at -mechanism-skin-hair.html

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