Ten researchers from the UI School of Medicine, from a team of 11 scientists, are responsible for the findings of a new study they conducted to investigate alternative ways to treat kidney infections. His work, which is published in the research journal Communications on Nature, examined how to use their own internal capabilities to fight kidney infections to treat and even prevent kidney infections, knowing that eventually antibiotics will not work.
According to statistics, urinary tract infections or UTIs are one of the most common bacterial infections affecting people of all ages. ITUs are getting more serious kidney infections, when bacteria rise from the bladder to the kidney. Kidney infections are common and occur each year in 13 out of 10,000 women and 4 out of 10,000 men. Kidney infections can cause high fevers, permanent kidney damage, or even sepsis. Additional data suggest that cases of antibiotic-resistant UTIs are on the rise, paving the way for more UTIs to become more serious kidney infections.
Specifically, the research team discovered that a type of kidney cell called “intercalated cells” consumes bacteria and secretes acid, which is a process known as phagocytosis and has historically been a capacity only associated with white blood cells.
“If I had to increase the activity of white blood cells to treat an infection, it would affect a person’s whole body. However, since we have found that these cells work in the same way, but are only present in the kidney, the long-term potential would be the ability to activate these cells to prevent or eliminate one infection of the kidney, “said Andrew Schwaderer, MD, a professor of pediatrics at the UI School of Medicine, and one of the study’s senior authors.” The idea is that with this approach we can replace or supplement antibiotic therapy. “
Interleaved cells exist at the exit of the kidney and can act as guardians; they are the first to find and consume bacteria when they invade the bladder kidney and then secrete the acid to neutralize it.
The researchers initially predicted this pathway by sequencing single-cell RNA available through the medical genomics core of the UI School of Medicine. Using normal human kidney tissue, they were able to sequence each interleaved cell individually, allowing them to explain exactly what happens in one cell type compared to the other. When advanced software scanned the file cells, the phagocytosis capabilities of these cells were predicted as a primary function.
“It was also interesting that we started with human tissue unlike mouse models and then returned to the mouse, said Vijay Saxena, Ph.D. and lead author of this study. “It’s a very partial way to study cell function and a very translational approach.”
The use of the IU School of Medicine’s O’Brien imaging center, one of only three available in the world, allowed researchers to imagine mice in real time, with live results. This approach is preferable to a cell culture system, which may or may not reflect what is happening in the human body.
Vijay Saxena et al, Interspersed kidney cells are phagocytic and acidify internalized uropathogenic Escherichia coli, Communications on Nature (2021). DOI: 10.1038 / s41467-021-22672-5
Indiana University School of Medicine
CitationResearchers discover a promising new way to prevent and treat kidney infections (2021, June 29) recovered on June 29, 2021 at https://medicalxpress.com/news/2021-06-kidney-infections.html
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