Researchers are creating viable mouse eggs from scratch for the first time

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A team of researchers affiliated with a host of institutions across Japan has created, for the first time, viable mouse eggs from scratch using stem cells. In his article published in the journal Science, the group describes their process and where they believe it could be used. Lin Yang and Huck-Hui Ng with the Genome Institute of Singapore have published a piece of Perspective in the same issue of the journal describing the work done by the team in Japan.

In 2011, pioneer of in vitro gametogenesis, Katsuhiko Hayashi and his team, produced the first sperm cells cultured from stem cells. Then, in 2016, Hayashi and another team produced the first mammalian eggs with stem cells. But this effort had a caveat: the precursor eggs had to be incubated in a bath of ovarian tissue to be viable. In this new effort, Hayashi and another team have overcome the need for ovarian tissue and created the first viable mouse egg. from scratch.

The team focused on the ingredients present in the ovarian tissue bath and developed a new incubator that did not require it. After five years, they found the right chemical mixture and used it to create an incubator bath that worked the same way as the ovary. bathroom. With all parts in place, the researchers produced oocytes in the way it had developed five years before. They then put them in the incubator bath and watched as the mixture turned into viable mouse eggs. The researchers made sure they were viable by inseminating several of them , implanting them in the uterus of a female mouse and letting nature follow its course. Artificially impregnated mice gave birth to offspring which were allowed to grow until they matured and reproduced naturally.

These experiments cannot be performed on humans, of course, but researchers suggest that their work may be applicable someday. —For example, allowing infertile women to have children, or even allowing same-sex couples to have children with DNA from both parents. Meanwhile, researchers are continuing their efforts and the next plan is to repeat their work with titis.


The Japanese team creates human oogonia using human stem cells in artificial mouse ovaries


More information:
Takashi Yoshino et al, Generation of ovarian follicles from pluripotent mouse stem cells, Science (2021). DOI: 10.1126 / science.abe0237

Lin Yang et al, The making of an ovarian niche, Science (2021). DOI: 10.1126 / science.abj8347

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Citation: Researchers create viable mouse eggs for the first time (2021, July 16) recovered on July 16, 2021 at https://medicalxpress.com/news/2021-07-viable-mice-eggs.html

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