Pfizer Jab less effective, still protects against Indian strain: study

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The Pfizer vaccine is a little less effective, but it still seems to protect against the most transmissible Indian strain of the virus that causes COVID-19, according to a study by the Institut Pasteur in France.

“Despite a slightly decreased efficiency, the Pfizer it probably protects “against the Indian variant, according to lab test results,” said Olivier Schwartz, director of the institute and co-author of the study published on the BioRxiv website before the peer review.

The study sampled 28 health workers in the city of Orleans. Sixteen of them had received two doses of the Pfizer vaccine, while 12 had received one dose of the AstraZeneca vaccine.

People who had received two doses of Pfizer saw a threefold reduction against the Indian variant, B.1.617, according to the study, but they were still protected.

“The situation was different with the AstraZeneca vaccine, which induced particularly low levels of antibodies that neutralized” the Indian variant, according to the study.

Patients who had had COVID-19 for the past year and people vaccinated with two doses of Pfizer retained enough antibodies to be protected against the Indian variant, but three to six times fewer antibodies than against the British variant, Schwartz said. .

The study shows that “this variant has acquired partial resistance to antibodies,” Schwartz said.

Since it first emerged in late 2019 in China, the SARS-CoV-2 virus that causes COVID-19 has developed several variants, usually named for the places where it first appeared, including strains called Southern strains. -Africa and the United Kingdom.

The variant first detected in India appears to be much more transmissible than previous variations.

It has now been officially registered in 53 territories, according to a report by the World Health Organization.

In an attempt to curb its expansion, France and Germany have again introduced stricter rules on arrivals from affected countries, including the United Kingdom.


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More information:
Delphine Planas et al, Reduced susceptibility of the infectious variant of SARS-CoV-2 B.1.617.2 to antibodies and monoclonal sera from convalescent and vaccinated individuals, BioRxiv (2021). DOI: 10.1101 / 2021.05.26.445838

© 2021 AFP

Citation: Pfizer Jab is less effective, still protects against Indian strain: study (2021, May 29) retrieved May 29, 2021 at https://medicalxpress.com/news/2021-05-pfizer-jab-effective- indian-strain.html

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