Although cardiovascular disease is the leading cause of illness among U.S. women, certain conditions such as microvascular coronary heart disease (CMD) cannot be easily diagnosed. In a new study, researchers at the University of Illinois Urbana-Champaign have identified specific biomarkers for CMD, which could reduce future hospitalizations.
CMD damages the interior walls of blood vessels, causing spasms and decreased blood flow to the heart muscle. “Clinicians are looking for plaque formation in the blood vessels, which does not occur in CMD,” said Zeynep Madak-Erdogan (CGD / EIRH / GSP), associate professor of nutrition. “Women usually leave without considering the root causes of chest pain and return with complications after one year. Since this condition is more common in postmenopausal women, we want to identify the biomarkers associated with CMD “.
The researchers picked up blood samples of three different groups containing 20 to 25 women each: postmenopausal women who were healthy, those who had coronary artery disease, which is characterized by plaque formation, and those with CMD. Blood serum samples were then analyzed for different molecules in the CMD group.
Of the 175 molecules scanned, the researchers identified stearic acid, which is found in animal and vegetable fats, and ornithine, an amino acid commonly found in meat, fish, diets and eggs, as indicators of CMD. .
Ornithine is formed from the amino acid arginine, which is broken down by two separate pathways. One forms ornithine and the other forms nitric oxide, which helps maintain the normal functioning of blood vessels.
“Our observations imply that increased ornithine means the second branch is not working, which is why we can use this molecule as a biomarker of the disease,” Madak-Erdogan said.
Interestingly, other researchers have found that estrogen may play a role in the development of CMD, as evidenced by hormone replacement therapies that reduce the risk of CMD by up to 30%. “Our observations further indicate that estrogen is involved because we know it improves the function of nitric oxide,” Madak-Erdogan said. “Because postmenopausal women have lower estrogen levels, it would explain why this condition is more common in these populations.”
Researchers are trying to identify more biomarkers, such as proteins, that can be used to detect CMD. In addition, they test more women to validate their findings. “This study was done with patients in Turkey, so we don’t know if there will be the same biomarkers in the United States. We want to examine larger populations to see if we can combine the data to find efficient signatures for CMD,” he said. Madak -Va dir Erdogan.
Alicia Arredondo Eve et al, Identification of circulating diagnostic biomarkers for coronary microvascular diseases in postmenopausal women using machine learning techniques, Metabolites (2021). DOI: 10.3390 / metabo11060339
University of Illinois at Urbana-Champaign
Citation: New markers for coronary microvascular disease have been identified (2021, June 30), retrieved July 1, 2021 at https://medicalxpress.com/news/2021-06-markers-coronary-microvascular-disease .html
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