New clinical indicators were discovered in transplant patients with COVID-19

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Researchers from 12 Spanish hospitals participated with the aim of discovering the clinical and prognostic characteristics in solid organ receptors with COVID-19. The findings emphasize the need for strict preventive measures in the initial period after transplantation.

Elisa Cordero, doctor of the Virgen del Rocío University Hospital, researcher at the Institute of Biomedicine of Seville (IBiS) and professor of the Department of Medicine at the University of Seville, led a study with researchers from 12 Spanish hospitals to study the clinical features and facilitate the prognosis of solid organ transplant recipients with COVID-19.

The study provides a more accurate description of the complications caused by COVID-19 in organ transplant recipients and has provided useful clinical indicators to identify the disease early. This makes it possible to determine therapeutic and care measures based on an individual assessment of each patient. The study highlights the need to take preventive measures with newly transplanted patients to avoid any risk of COVID-19 infection.

“This study found that SARS-CoV-2 infection is more severe in patients who have received a solid organ transplant, especially in the first few months after the transplant. Therefore, it is very important to take strict precautions.” , emphasizes Dr. Cordero.

The project received the support of the Instituto de Salud Carlos III (ISCIII), of the Spanish Ministry of Science and Innovation, through the call for Research Projects on SARS-CoV-2 and COVID-19 (COV20 / 00370) and the ISCIII Clinical Research Support Platform.

The study in figures

A total of 210 patients with COVID-19 were analyzed, of whom 140 (70.5%) were men with a mean age of 63 years. It was found that 90% of patients suffered from pneumonia, with the most common symptoms being fever, cough, gastrointestinal disorders and dyspnea.

Seventeen percent of patients needed admission to intensive care units and 5.7% suffered graft dysfunction. The study concluded with a mortality rate among the patients in the sample of 21.4%, i.e., 45 of the 210 patients studied died. Some of the factors associated with the need to admit patients to intensive care or, indeed, mortality, were advanced age, respiratory failure, lymphocyte drop, and elevated lactate dehydrogenase enzyme.


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More information:
Sonsoles Salto-Alejandre et al, Risk factors for adverse outcomes and impact of early infection after transplantation into solid organ receptors with COVID-19: a prospective multicenter cohort study, PLOS ONE (2021). DOI: 10.1371 / journal.pone.0250796

Citation: New clinical indicators discovered in COVID-19 transplant patients (2021, July 2) recovered on July 3, 2021 at https://medicalxpress.com/news/2021-07-clinical-indicators-transplant-patients-covid -.html

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