Nanoparticle-based fluorescence imaging supports tumor diagnosis


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A malignant tumor (cancer) represents a new organism formed by in vivo mutation of normal cells. It can grow continuously and escape the elimination of the immune system. Therefore, early diagnosis and treatment are essential for inhibiting tumor growth.

Unlike conventional media, bioimaging has the potential to accurately locate and diagnose tumors in an early stage using methods of characterization, visualization, and quantification of physiological processes at the cellular and molecular levels. However, the low resolution and dangerous ionizing radiation of the image by CT, PET and SPECT, as well as the high time consumption by the PAI image and magnetic resonance imaging limit its application in the treatment of the disease.

In a study published in Journal of Luminescence, a research team led by Professor Dr. Peng Bo of the Xi’an Institute of Optics and Precision Mechanics (XIOPM) of the Chinese Academy of Sciences (CAS) proposed a biocompatible, non-toxic, near-infrared biocompatible fluorescent tumor aimed at nanoparticles ) KHLF (K5HoLi2F10) for of tumor.

The preparation of KHLF NPs is according to the atypical hydrothermal method. CH3CH2Okay, I have it (NO3)36H2Oh, and LiNO3 were prepared respectively in aqueous solutions of a certain concentration by dissolution in deionized water. After mixing them, PEG was added to the mixture and stirred evenly.

The researchers modified APTES to the new NP doped with Ho3+ by a step-by-step method and covalently linked (FA) on the surface to provide it with water solubility and tumor orientation. The results of the FTIR and zeta potential confirmed the modification process.

The latter the images showed that AF modification did not significantly weaken the fluorescence intensity of NPs. Biodistribution images, in vivo images, in vitro images of various organs, and tumor orientation imaging experiments were performed. The results showed that this nanoparticle can accurately accumulate on the HeLa tumor and generate a strong fluorescence signal.

The proposed nanoparticle-based fluorescence image has great potential as an efficient biocompatible fluorescent contrast agent for diagnosis.

The new method allows orthotopic brain tumor images to be clearer and faster

More information:
Q. Fan et al, Tumor image of a new biocompatible NIR fluorescent fluoride nanoparticle based on Ho3 +, Journal of Luminescence (2021). DOI: 10.1016 / j.jlumin.2021.118007

Citation: Nanoparticle-Based Fluorescence Image Supports Tumor Diagnosis (2021, May 24) Retrieved May 24, 2021 at -tumor.html

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