Multidisciplinary fecal immunochemical tests increase diagnostic accuracy


(HealthDay): A multitarg fecal immunochemical test (mtFIT) shows better diagnostic accuracy for detecting advanced neoplasia than standard FIT tests, according to a study published online July 20 Annals of Internal Medicine.

Willemijn de Klaver, MD, of the Dutch Cancer Institute in Amsterdam, and colleagues made a diagnosis study to develop an mtFIT with better diagnostic performance than FIT. Participants included 1,284 people from a detection and referral population who were classified for their most advanced injuries and 769 controls. To identify the optimal combination to detect advanced neoplasia, a classification and regression tree (CART) analysis was applied to biomarker concentrations.

The researchers found that the combination of hemoglobin, calprotectin, and F 2 family member serpentine (mtFIT) had a cross-validated sensitivity of 42.9% for advanced neoplasia compared with 37.3% of FIT in the CART analysis, with an equal specificity of 96.6%. . For advanced adenomas, cross-validated sensitivity increased from 28.1 to 37.8 percent. Based on these results, early evaluation of healthcare technology suggested that, compared to FIT, mtFIT-based screening could be cost-effective.

“This study provides a more validated clinical validation of an mtFIT to detect advanced neoplasia, particularly advanced adenoma, compared with FIT,” the authors write. “The fact that, from both a logistical and economic point of view, mtFIT could be compatible with the current practice of FIT programs can greatly facilitate the future implementation of mtFIT. “

Several authors have disclosed pending patents on early detection of colorectal cancer.

The index stratifies the risk of advanced colorectal neoplasia

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