An international team of experts in multiple sclerosis (MS) has identified four little-researched areas that are critical to advancing the management of progressive MS symptoms, recommending interdisciplinary collaboration between scientists, clinicians, industry leaders, and those with progressive MS. His call to action was published in Journal of Multiple Sclerosis on March 15, 2021, in the article “Prioritizing Progressive Research on MS Rehabilitation: A Call from the International Alliance for Progressive MS”. The Alliance was represented by authors from Canada, the United States, the United Kingdom, Australia, Denmark, Belgium, Germany, and Switzerland.
Recent advances in MS research have resulted in a variety of disease-modifying therapies that can significantly improve life quality for people with certain phenotypes of the disease. For example, those with recurrent-remitting MS have access to more than 20 therapies. However, these phenotypes only represent some in the MS community.
An important barrier to the development of rehabilitation therapies for progressive MS is the fact that the vast majority of studies conducted to explore rehabilitative therapies involve people with recurrent-remitting MS, not progressive MS. In addition, trials are often designed based on strategies used for pharmaceutical trials, which are not necessarily conducive to clinical rehabilitation trials. Unfortunately, this lack of clinical data to inform therapies for progressive MS leaves this population with few options for managing potentially debilitating symptoms that can lead to challenges such as job loss, personal and family stress, and financial stress.
In this paper, experts in research, medicine, and industry highlight four main symptoms affecting people with progressive MS that should be the focus of new research: fatigue, mobility, and upper limb impairment, pain, and impairment. cognitive. They argue that rehabilitative therapies show great promise for managing these symptoms and improving physical and cognitive function, as well as quality of life, and that directing research efforts toward rehabilitation is critical to developing effective therapies.
“There is a great need to study the effect of early preventive interventions and evaluate the management of existing symptoms,” says co-author John DeLuca, Ph.D., senior vice president of research and training at the Kessler Foundation. “Cash symptom management and rehabilitation lag far behind in progressive MS. We have little data on empirical rehabilitation and our understanding of the mechanisms underlying symptoms and responses to treatment is incomplete. “Dr. DeLuca stresses,“ We have extensive evidence from research in other clinical areas that rehabilitation can improve quality of life and find support from various contributors. and stakeholders. Our goal is to draw attention to the urgent need to develop rehabilitation treatment interventions for the progressive MS community. ”
Kathleen M Zackowski et al, Prioritizing Progressive Research on MS Rehabilitation: A Call from the International Progressive MS Alliance, Journal of Multiple Sclerosis (2021). DOI: 10.1177 / 1352458521999970
Provided by the Kessler Foundation
Citation: MS experts call for greater focus on progressive MS rehabilitation research (2021, May 28), retrieved May 29, 2021 at https://medicalxpress.com/news/2021-05-ms -experts-focus.html
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