Loss of circadian regulation increases glucose production during lung cancer

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During the progression of lung cancer and the corresponding development of cachexia, circadian control of glucose production is disrupted, leading to an increase in liver glucose levels. These findings illustrate a tissue-tissue interconnection by which a lung tumor can alter the circadian metabolism of a distal tissue, potentially for its own growth advantage. Credit: UCI Faculty of Medicine

New research from the University of California, Irvine, reveals how circadian regulation of glucose production in the liver is lost during the progression of lung cancer and how the resulting increase in glucose production can fuel cell growth. · Carcinogenic cells.

The new study entitled “Glucagon regulates the stability of REV-ERBα to modulate the liver in a model of cachexia associated with lung cancer “, published today in Scientific advances, illustrates how is regulated under stressful conditions, such as during the progression of lung cancer and cancer-associated tissue wear disease called cachexia

“Our research shows that a critical circadian protein, REV-ERBα, controls the production of glucose in the liver. During the progression of lung cancer and specifically in cachexia conditions, this circadian regulation is lost, which translates into an increase. of glucose production in the liver, ”senior said. author Selma Masri, Ph.D., assistant professor in the Department of Biological Chemistry of the UCI Faculty of Medicine. “Based on our findings, we identified that lung tumors are able to provide instructive clues to the liver to increase glucose production, an important factor for cancer cells “.

This research places the circadian clock as a central regulator of glucose production during the progression of lung cancer and provides an important insight into the development of new therapeutic methods aimed at REV-ERBα to suppress .

“We continue to investigate the consequence of increased glucose production during the progression of lung cancer by tracking the metabolic fate of this newly generated to determine if this fuel source can lead to increased metabolic demand from the lung “said Amandine Verlande, Ph.D., and Sung Kook Chun, Ph.D., postdoctoral scholars at Masri Laboratory.

The circadian clock is our intrinsic biological pacemaker that maintains physiological homeostasis in all tissues of the body. Under stressful conditions, the biological clock reconnects as an adaptive mechanism to maintain synchrony and balance throughout the body.


According to the study, lung tumors sequester the metabolic processes of the liver


More information:
Amandine Verlande et al, Glucagon regulates the stability of REV-ERBα to modulate hepatic glucose production in a cachexia model associated with lung cancer, Scientific advances (2021). DOI: 10.1126 / sciadv.abf3885

Citation: Loss of circadian regulation increases glucose production during lung cancer (2021, June 26) recovered on June 26, 2021 at https://medicalxpress.com/news/2021-06-loss-circadian- glucose-production-lung.html

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