Drink any type of coffee associated with a reduced risk of chronic liver disease


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Drinking coffee with caffeine (ground or instant) or decaffeinated is associated with a reduced risk of developing chronic liver disease and related liver conditions, according to a study published in the open access journal BMC Public Health.

Researchers at the universities of Southampton and Edinburgh, UK, found that drinking any type of coffee was associated with a reduced risk of developing and dying from chronic liver disease compared to not drinking coffee, with a benefit maximum of three to four cups a day.

The authors studied data from the UK Biobank on 495,585 participants with known coffee consumption, who were followed for an average of 10.7 years to monitor who developed chronic liver disease and related liver conditions.

Of all participants included in the study, 78% (384,818) consumed soil or instant caffeine or , while 22% (109,767) did not drink any coffee. During the study period, there were 3,600 cases of chronic liver disease, including 301 deaths. In addition, there were 5,439 cases of chronic liver disease or steatosis (an accumulation of fat in the liver also known as ), and 184 cases of hepatocellular carcinoma, a type of liver cancer.

Compared to those who did not drink coffee, coffee consumers had a reduced risk of chronic liver disease by 21%, a reduced risk of chronic liver disease or 20% and 49% of death from chronic liver disease. The maximum benefit was seen in the group that drank ground coffee, which contains high levels of Kahweol and cafestol ingredients, which have been shown to be beneficial against chronic liver disease in animals.

Instant coffee, with low levels of Kahweol and cafestol, was also associated with a reduced risk of chronic liver disease. Although the risk reduction was less than that associated with ground coffee, the finding may suggest that other ingredients, or potentially a combination of ingredients, may be beneficial.

Dr Oliver Kennedy, lead author, said: “Coffee is widely available and the benefits we see from our study may mean it could offer potential preventive treatment for chronic liver disease. This would be especially valuable in higher-income countries. low and worse access to health and where the burden of is higher “.

The authors warn that, as it was only reported when participants first enrolled in the study, the study does not take into account any change in the amount or type of coffee they consumed during the 10.7-year study period. Because participants were predominantly white and with a higher socioeconomic background, the findings may be difficult to generalize to other countries and populations.

The authors suggest that future research could prove the relationship between coffee and coffee disease with stricter control of the amount of consumed. They also propose to validate their results in more diverse groups of participants.

Calculating the reduction in global deaths from liver cancer if everyone drank more coffee

More information:
All types of coffee decrease the risk of adverse clinical outcomes in chronic liver disease: a study by the UK Biobank, BMC Public Health 2021 DOI: 10.1186 / s12889-021-10991-7

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BioMed Central

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