Cellular concealment to reduce the foreign body’s response to medical implants

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Researchers at the Korean Institute of Science and Technology have developed a technique for coating implantable materials, such as stents, with extracellular matrix components and cells. The new approach could lead to implantable devices that suffer fewer adverse events, such as fibrosis, inflammation, and clotting, due to the foreign body’s response.

All implantable devices suffer from the same limitation: the foreign body response. It is difficult to get the body to accept a foreign object and the foreign body’s response is behind most implant failures, especially in devices intended for a long-term stay inside the body. The body normally reacts to foreign objects through fibrosis and inflammation, which can affect other effects, such as blood clotting. In long-term implants such as stents, these phenomena can lead to device failures or unacceptable safety issues, leading to the need for additional procedures and treatments.

Researchers have developed a wide variety of device coatings in an attempt to reduce or prevent the foreign body’s response, and these have had mixed success. The latter technology is based on extracellular matrix coating devices and then therapeutic cells, in an attempt to reduce the foreign body response and provide therapeutic benefits at the same time.

“This technology can be used to improve various materials that are inserted into the human body,” Yoon Ki Joung, a researcher involved in the study, said in a press release. “Therefore, it is hoped to provide a universal platform for the development of implantable diagnostic and treatment devices (that can dictate the future of technology in the field) and medical devices such as stents and implants that require long-term implantation.” .

The technique involves coating a material with polydopamine and fibronectin, and then preculting it with cells that deposit a layer of extracellular matrix on the surface of the material. The researchers then remove the cell layer and replace it with a layer of therapeutic cells. In the case of a stent, they experimented with a surface layer of endothelial progenitor cells, which can help regenerate the endothelium.

Live-growth endothelial cells stained with calcein adhered to a bare metal stent (BMS) and a pDA / FN / ECM-coated stent, respectively.

So far, the stent has been tested on a pig model. Demonstrated endothelial regeneration in situ, and compared favorably with other tested stents. With subsequent work, these cell-loaded surfaces can help improve the long-term prospects of implanted materials.

Study a Advanced functional materials: A robustly supported extracellular matrix improves the efficiency of intravascular delivery of endothelial progenitor cells.

Via: South Korea National Science and Technology Research Council





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