This excerpt is adapted from The essential guide to CBD by the editors of Reader’s Digest and Project CBD.
Leading researchers a WE National Institutes of Health (NIH) recognize the importance of the endocannabinoid system as a crucial health point. This is highlighted in a 2013 report by NIH scientists Pal Pacher and George Kunos, who argue that “modulation of endocannabinoid system activity may have therapeutic potential in almost all diseases affecting humans.”1
It depends a lot on how the two subtypes of cannabinoid receptors: CB1 i CB2 – function. Both the liver and the kidneys (and other) internal organs, the CB1i CB2 the receptors have a kind of yin-yang relationship. When the CB1 the receptor is overstimulated and not enough CB2 receptor signaling, or vice versa, follows various diseases.2
Chronic liver disease is a major public health problem that affects hundreds of millions of people worldwide. Fatty liver, kidney disease, diabetes and other diet-related metabolic disorders are expressions of hyperactivity CB1 receiver signaling and inadequate CB2 receptor stimulation. CBD perfects the endocannabinoid system by downloading the file CB1 dimmer switch while mimicking and magnifying CB2 activity.
In the liver and kidneys specifically, CB1 signaling is profibrotic, that is, it promotes the development of fibrous connective tissue in response to injury or damage. CB2 the signaling is antifibrotic, that is, it prevents fibrosis and dilutes the blood. When CB1 i CB2 they are unbalanced, they can cause fibrosis or dangerous scars on these organs. Liver cirrhosis and non-alcoholic liver disease are two serious conditions that are marked by too much fibrosis, which is also a feature of chronic kidney disease.
Effective treatment strategies for fibrotic conditions should aim to increase CB2 signaling, while refining CB1 in the other direction. This is CBD does, and so it is CBD it can help prevent disease and keep the liver and kidneys healthy.3 4
CBDLiver protection capacity was the focus of a study published in 2017 in the journal Scientific reports, which examined the effect of CBD in mice given enough ethanol to mimic chronic and excessive alcohol use. The study verified this CBD the oil minimizes fat accumulation and liver damage. The authors concluded:CBD may have therapeutic potential in the treatment of alcoholic liver disease associated with inflammation, oxidative stress and steatosis [fatty change], which deserves an exploration in human tests “.5
In another study that examined the impact of CBD on liver health in animals, the researchers gave laboratory rats CBD and other cannabinoids for eight months. Published in Death and cell disease, the study found that CBD killed liver stellate cells, which trigger scar tissue in the liver.6
“Not only does it seem that there is no evidence to prove it CBD plays a role in liver damage over a long period of time, ”the scientists reported,“ it actually appears that cannabinoids can help improve liver health and reduce the effects of any damage done to it. More studies are still needed, especially those involving human participants. However, current evidence seems to support the notion that CBD the use of oil is not only safe, but can even play a potentially therapeutic role in the treatment of liver disease ”.7
This assessment calls into question food & Warnings of drug administration, based on weak evidence, that CBD can damage the liver.
A fragment of The essential guide to CBD by the editors of Reader’s Digest & Project CBD.
Copyright, project CBD. Cannot reprint without permission.