Book excerpt: Autism and endocannabinoid dysfunction


This excerpt is adapted from The essential guide to CBD by the editors of Reader’s Digest and Project CBD.

The number of children diagnosed with autism spectrum disorders (TEA) worldwide has tripled in the last 30 years. There is now undeniable evidence that deregulation of the endocannabinoid system is involved and that some people have TEA they have a low endocannabinoid tone.

In 2019, in a review paper entitled “Participation of the endocannabinoid system in autism spectrum disorder: an overview with possible therapeutic applications,” the researchers concluded, “Recent evidence reveals a strong participation of the CE in the pathophysiology of some neuropsychiatric disorders and TEA…. In addition, literature evidence indicates this CBD it can alleviate many conditions that occur together TEA, such as seizures, gastrointestinal problems, anxiety and depression, attention deficit and sleep problems. “1

The parents seem to agree. In 2019, Israeli researchers surveyed the parents of 53 children and young adults ages 4 to 22 who received oral drops of CBD oil for an average of 66 days.2 Self-harm and rabies attacks improved by almost 68%, hyperactivity by 68%, 71% slept better, and 47% had less anxiety. In some cases, the symptoms got worse: 24% seemed to be more anxious, for example. Otherwise, the results were mostly positive and adverse side effects, mainly changes in appetite and sleep sensation, were mild.

Another study published in Nature in 2019 data from 188 children with TEA which were treated with medicinal cannabis, mostly CBDcannabis-rich oil: between 2015 and 2017. After six months of treatment, just under a third of participants reported significant improvements and more than half reported moderate improvements, according to quality of life questionnaires measuring the mood and ability to function independently.3

Of course, more research is needed to provide more specific recommendations, but in the meantime, it’s worth talking to a professional who is well-versed. CBD and cannabis therapy. In some cases, children can have noticeable improvement with very small doses, says Bonni Goldstein, MD, author of Cannabis is medicine and medical director of Canna-Centers, a California-based medical practice dedicated to educating patients about the use of cannabis for serious and chronic medical conditions.

“I had a patient, a small child, coming in with autism,” Goldstein said, “and the parents were desperate. So they tried a little bit, and I mean a little bit. CBD – Before entering my office, I was told that after a week with this very low dose, the teacher had already noticed that the child was getting better. The teacher didn’t know he was CBD oil. But one day at the end of school, he pretended to be a line of interest to his mother and said, “Okay, what’s going on? What’s different? At this small dose, such as about 4 or 5 milligrams, they saw this incredible benefit in this child.4

Across the spectrum, Dr. Goldstein also sees patients who need much higher doses, and no one can really tell why, why. CBD it works at the cellular level and is not easy to measure. “There’s no way to know by the size or level of someone’s illness exactly what will suit them. You won’t know until you try to see it,” he says.

A fragment of The essential guide to CBD by the editors of Reader’s Digest & Project CBD. Copyright, project CBD. Cannot reprint without permission.

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