A group of scientists based in Australia are looking to make poison from a deadly native spider to save lives by stopping the harmful effects of heart attacks.
The researchers used the venom of a type of funnel net spider (among the deadliest species in the world) in a drug they hope could soon be taken to human testing.
So far the experimental medicine it has only been tested in the laboratory.
University of Queensland scientist Nathan Palpant said Friday that the poison helped prevent the body from sending a “death signal” after a heart attack, which kills cells.
“After a heart attack, blood flow to the heart is reduced, causing a lack of oxygen. heart musclePalpant said.
“Lack of oxygen causes the cellular environment to become acidic, which combines to send a message to cause heart cells to die.
“Despite decades of research, no one has been able to develop a drug that stops this signal of death in heart cells, which is one of the reasons why heart disease it remains the leading cause of death in the world. “
The team has successfully used a spider venom protein to beat human heart cells to which they were exposed. heart attack tensions.
“Spider venom Hi1a protein blocks the ion channels that detect acid in the heart, so the death message is blocked, cell death is reduced, and cell survival is seen to be improved. heart cells, “Palpant said.
It is hoped that the drug can help not only prevent heart damage and save lives, but also improve the quality of hearts given during transplants.
Previous research has indicated that funneled spider venom may also be helpful in curbing blow damage.
The University of Queensland said the team had the goal clinical trials in humans for both stroke and heart disease “within two to three years.”
The most recent research was published in the latest issue of the journal Circulation.
Meredith A. Redd et al, Therapeutic inhibition of ion channel 1 of acid detection recovers heart function after ischemia and reperfusion injury, Circulation (2021). DOI: 10.1161 / circulationaha.121.054360
© 2021 AFP
Citation: Australian scientists see potential savior in spider venom (2021, July 16) recovered on July 16, 2021 at https://medicalxpress.com/news/2021-07-aussie-scientists-life-saving -potential-spider.html
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