A new study from the University of California, led by Irvine, reveals that albumin (Alb), one of the body’s most abundant proteins, activates a proton channel (hHv1), also widespread in the body, giving sperm the ability to of penetrating and fertilizing an egg, and allowing white blood cells to secrete large amounts of inflammatory mediators to fight infection.
The study entitled “Direct activation of proton channel by albumin leads to the training of human sperm and the sustained release of inflammatory mediators by neutrophils, “it was published today in Communications on Nature.
The researchers examined the physiological connection between proton channels (HHv1) closed by human stress and Alb, which are essential for cell biology in health and disease. They also demonstrated the mechanism by which Alb binds directly to hHv1 to activate the channel. This research explains how sperm fertilization is triggered and neutrophils are stimulated to release mediators in the innate immune response, describing a new role for Alb in physiology that will operate on the many tissues that express hHv1.
“We found that the interaction of Alb and hHv1 activates sperm when they leave semen and enter the female reproductive system because Alb has low semen content and a high content in the reproductive tract. We now understand why albumin supplementation improves IVF, “said first author Ruiming Zhao, Ph.D., of the UCI Department of Physiology and Biophysics.” We also found that the same Alb / hHv1 interaction allows white blood cells called neutrophils to produce and secrete inflammatory mediators that kill bacteria and fight infections. However, it is important to note that the file inflammatory response “The essential stimulatory role of Alb in the physiology of sperm and neutrophils through hHv1 suggests that Alb will have harmful or enhanced functions not yet recognized in other tissues, including the central nervous system, the heart. and lungs, and will affect breast and gastrointestinal tract cancers.
“It’s exciting to discover that a common protein has the power to activate the proton channel. This finding suggests new strategies to block or increase fertility and increase or suppress fertility. innate immune response ” of Pharmacy and Pharmacy Sciences.
The hHv1 proton channel is involved in a wide range of biological processes, in addition to sperm training and the innate immune responses included in the study. Channels play a notable role in cancer cell proliferation, tissue damage during ischemic stroke, and hypertensive kidney injury. Because Alb is ubiquitous at varying levels in different human compartments in health and disease, the potentiation of HHv1 by Alb described in the paper will be widespread, tissue-dependent, and will play both a healthy and unfavorable role in human physiology.
“We have modeled the structural basis for the binding of Alb to the channel leading to activation and changes in cell function, and we are now conducting in vivo studies of viral and bacterial infections. Our next steps include studies of the effects of the inhibitors of the Alb-hHv1 interaction on infection, inflammation and fertility, “Goldstein said.
The study was a grant from the National Institutes of Health, US-Israel Binational Science Foundation, Cuyo National University, Argentina, National Agency for Scientific and Technological Promotion, Argentina, Que el National University, Argentina, National Agency for Scientific and Technological Promotion Tecnologica, Argentina, National Autonomous University of Mexico, General Direction of Subjects of the Academic Personnel, and National Council of Science and Technology, Borders.
Ruiming Zhao et al, Direct activation of the proton channel by albumin leads to the training of human sperm and the sustained release of inflammatory mediators by neutrophils, Communications on Nature (2021). DOI: 10.1038 / s41467-021-24145-1
University of California, Irvine
Citation: A study found that the most common protein in the blood is essential to allow human fertilization and fight infection (2021, June 22) recovered on June 22, 2021 at https://medicalxpress.com/news/2021 -06-common-protein-blood-instrumental- enable.html
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