A new study shows significant inflammatory responses after meals


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New research has shown that acute and prolonged food-induced inflammation may increase the predicted risk of developing cardiometabolic diseases such as cardiovascular disease.

The study, published today in American Journal of Clinical Nutrition, is the world’s deepest in-depth study to analyze postprandial inflammation. The researchers found that the inflammation, triggered by , varies greatly between individuals.

Researchers from King and health science company ZOE were able to identify for the first time the relative influence of i on inflammation, demonstrating a stronger link with blood fat responses than blood sugar. These findings highlight the potential of personalized strategies to reduce chronic inflammation in preventive health.

Led by Dr. Sarah Berry and her team, in collaboration with Massachusetts General Hospital and additional researchers in the United States, the United Kingdom, Italy, Spain, and Sweden, the PREDICT study invited 1,002 participating in the PREDICT research program to enter the team’s research clinic for one day. They were all given two standardized meals, each containing precise amounts of fats, carbohydrates, fiber, and protein: breakfast (a cupcake and a smoothie) and lunch four hours later (a cupcake).

The researchers took blood samples from participants before breakfast and at nine points throughout the day. They were then analyzed to measure blood fat and sugar levels at different time points, along with levels of two markers of inflammation, interleukin 6 (IL-6) and glycoprotein acetylation (GlycA). . The researchers also collected detailed health data from participants, including information about their typical diet, a fecal sample for microbiome analysis, and an exploration of body fat.

The researchers found that levels of inflammation after eating varied widely among participants, including identical twins, even though everyone had the same meals at the same intervals.

People with more body fat and a higher body mass index (BMI) were more likely to have higher levels of inflammation after eating, which supports the current evidence that obesity control will reduce obesity. chronic inflammatory load. Inflammation levels also tended to be higher in men than in women and in participants older than younger ones.

Several strategies were recommended to reduce the impact of inflammation after eating.

  • Control unhealthy blood fat responses by choosing whole foods that have more fiber and lean protein, increasing your intake of healthy omega-3 fats from sources such as fish, nuts, and seeds, and reducing overall body fat.
  • Control unhealthy blood sugar responses by choosing foods that contain carbohydrates and complex fiber, such as whole grains, fruits, and vegetables, and limiting sugary processed foods and soft drinks.
  • Reduce inflammation after eating by choosing foods that have “anti-inflammatory” bioactive molecules, such as polyphenols, found in colored fruits and vegetables and other plant foods.
  • Understand your biology and choose foods that are less likely to cause unhealthy blood fat or sugar responses after eating

Tim Spector, professor of genetic epidemiology at King’s and co-founder of ZOE, adds: “Previous results from our PREDICT study showed that the combination of microbes living in our gut, known as the intestinal microbiome, is closely linked to our way of responding to foods, particularly fats.We have also found that the composition of the microbiome is strongly associated with GlycA levels, which opens the door to the reduction of food-related foods. and improving health by manipulating the microbiome “.

An iconic study shows that inflammation after meals varies dramatically among healthy adults

More information:
Mohsen Mazidi et al, Meal-induced inflammation: postprandial studies of the study of personalized responses to the dietary composition process (PREDICT) in 1000 participants, The American Journal of Clinical Nutrition (2021). DOI: 10.1093 / ajcn / nqab132

Citation: New study shows significant inflammatory responses after meals (2021, June 11) retrieved June 12, 2021 from https://medicalxpress.com/news/2021-06-significant-inflammatory-responses-meals.html

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