5 Best Liver Supplements of 2021: The Ultimate Guide – Health Guild Report


The liver is one of the most important organs in our body, performing a wide range of essential tasks. It’s a half-moon-shaped organ located in the right upper part of the stomach and is responsible for critical metabolic and immune health functions. The liver is also responsible for filtering out toxic substances from the blood, producing bile for digestion, metabolizing sugar, and more.

The liver is essential for living a healthy life, and it’s almost impossible to survive without a well-functioning liver. However, this delicate organ is vulnerable to many dangerous factors, both internal and external. Research suggests that the liver is susceptible to many diseases, including cirrhosis, cancer, and Hepatitis B and C. Environmental toxins and lifestyle factors like excessive alcohol and tobacco also play a role.

The good news is that it’s possible to keep the liver in excellent shape with a combination of healthy lifestyle choices and high-quality supplements. Here are 5 of the best liver health supplements you can buy in 2021:

5 Best Liver Detox Products in 2021

The liver can take a beating due to a variety of factors, including  excessive alcohol consumption, high BMI, abuse of prescription medication, and even certain viruses. This is where a good liver health supplement can make a massive difference. A premium natural liver detox supplement can gently repair liver damage while also optimizing function. When looking for a liver health supplement, it’s important to do your research. There are many dubious brands in the market, and you want to keep away from those. 

We have taken the pain of researching the whole market, so you don’t have to. Here are 5 of the very best liver detox supplements you can buy in 2021:

Oweli Liver Detox

Oweli has garnered a reputation in recent times for its solid line of supplements. Oweli’s Liver Detox is an herbal blend formula with powerful ingredients which reduce oxidative stress, optimize liver protection and help boost immunity. 

The carefully selected ingredients list looks very impressive. It includes milk thistle, beetroot, artichoke extract, and chanca piedra for antioxidant supply and dandelion, which contains polysaccharides that reduce stress on the liver and support bile production. Oweli Liver Detox also contains zinc, which is a key mineral that helps prevent liver inflammation.

Oweli Liver Detox puts safety first and is manufactured in FDA-registered facilities and is cGMP compliant. It is free of harmful pathogens, pesticides, and heavy metals. All these efforts underline Oweli’s trustworthy product quality. It also offers a generous and unconditional 100-day money-back guarantee which makes it a perfect first-time pick. 

Finally, Oweli Liver detox is priced as low as $29.99, making it very cost-effective. All in all, it ticks all boxes and is the best liver detox supplement you can buy.

Verdict: Top pick

Clinical Effects Liver Support

Clinical Effects is well-renowned for its reliable line of supplements. Liver Support by Clinical Effects uses a blend of natural plant extracts including milk thistle to support liver health and aid the body’s detoxification process. It also contains useful ingredients like zinc, artichoke, dandelion, chanca piedra and yarrow.

Clinical Effects Liver Support is priced at $34.95 for a one-month supply, and all dosages are transparent, making it very simple to compare it to other liver health supplements marketed online. All in all, this is a solid product worth its price.

Verdict: Reliable choice

Organifi Liver Reset

Organifi Liver Health Formula is the most recognized liver support supplement on the market in 2021. It’s a well-known brand with a history of delivering efficient supplements straight to the customer. 

It contains artichoke, triphala, milk thistle, and dandelion root, which are considered to be beneficial for the liver. The ingredients are all natural and organic and have been used in traditional medicine for centuries. 

Liver Reset is backed by a 60-day money back guarantee. At $27.95, Organifi Liver Reset is a good deal if you’re looking for a supplement with minimal natural ingredients.

Verdict: Cost-effective pick

Price: $27.95

1MD LiverMD

1MD is a popular brand with its main advantage being its easy availability. It’s products are available both online and at retail outlets.  Its main ingredient, milk thistle, has been known to have an antioxidant effect that protects liver cells from damage. Moreover, the supplement also contains a generous dose of N-acetylcysteine, which may help protect against medication-induced liver damage.

At $45 per bottle, the product is more expensive than some others on this list. However, considering all the benefits, it’s not an unfair bargain at the end of the day.

Verdict: Expensive but accessible

Price: $45.00

Amy Myers MD Liver Support

Amy Myers MD is a trusted brand with many positive reviews to back up its reputation. Liver Support by Amy Myers MD features a blend of ingredients to help detoxify and optimize liver function. The supplement contains 200 mg of NAC that acts as a precursor to glutathione, which is beneficial for the liver. It also contains alpha-lipoic acid to help scavenge free radicals.

At $34.95 per bottle, you get 60 capsules with a recommended dose of one capsule per day. Considering its list of powerful ingredients, this product is a solid buy.

Verdict: Good choice

Price: $34.95

What are the Most Commonly Used Active Ingredients in Liver Supplements? 

Research has discovered many natural ingredients that are highly efficient in maintaining and improving liver health. Here are some of the most commonly used ingredients that the best liver detox supplements use:

Milk Thistle 

Milk thistle (silymarin) is a flowering herb related to the daisy and ragweed family. It is native to Mediterranean countries. People have traditionally used milk thistle for problems with the liver and gallbladder. 

When it comes to detoxification, the liver handles a massive workload. As a potent antioxidant, Milk Thistle helps fight off free radicals so your liver can keep flushing out toxins and protecting your other organs as it should.


Dandelions are a family of flowering plants that grow in many parts of the world. For centuries, they’ve been used to treat a myriad of physical ailments, including cancer, acne, liver disease and digestive disorders.

The polysaccharides present in dandelion are known to help reduce stress on the liver and support its ability to produce bile. They can also help your liver filter out potentially harmful toxins present in food.


Artichoke originated in the Mediterranean and has been used for centuries for its potential medicinal properties. Its purported health benefits include lower blood sugar levels and improved digestion, heart health, and liver health.

Artichoke extract helps protect your liver from damage and promotes the growth of healthy tissue. It also supports the production of bile, which helps remove harmful toxins from your system.

Beet Root

Beetroot is packed with essential nutrients, beetroots are a great source of fiber, folate (vitamin B9), manganese, potassium, iron, and vitamin C. Beetroots have numerous health benefits, including improved blood flow, lower blood pressure, and increased exercise performance.

Beetroot extract contains antioxidants, vitamin A, vitamin B-6, and iron. These nutrients help shield the liver from inflammation and oxidative stress while boosting its ability to flush toxins from the body.

Chanca Piedra

Chanca piedra is an herb that grows in tropical areas, like the rainforests of South America. As a supplement, chanca piedra is reported to help with a variety of conditions related to the digestive system, liver, and kidneys.

Chanca piedra’s antioxidant properties help support optimal liver function. It can also help protect your liver from cellular damage triggered by free radicals, which can be harmful in excess quantities.


Chicory is a blue flowering plant and a member of the dandelion family, which grows across North America and parts of Europe. Chicory root is a good source of inulin, which is a type of fiber. It also contains a variety of antioxidants, vitamins, minerals, and fibre.

Research shows that chicory extract is very rich in natural antioxidants and highly effective at filtering harmful free radicals. It can potentially boost the immune system of the body while also cleansing the liver.


Yarrow (Achillea millefolium) has been used for thousands of years for its potential health benefits. Its genus name, Achillea, refers to the warrior Achilles in Greek mythology, as he used yarrow to treat his soldiers’ wounds

Yarrow is widely known for its ability to help resist liver inflammation. Yarrow is also known to support dilation of the capillaries, which in turn encourages blood circulation.


Zinc is the second-most-abundant trace mineral in your body and is present in every cell. Zinc is necessary for the activity of over 300 enzymes that aid in metabolism, digestion, nerve function, among others.

Zinc deficiency may alter hepatocyte functions and also immune responses in inflammatory liver conditions. Zinc supplementation can help maintain optimal liver function.

Symptoms of liver disease

Liver issues can be hard to detect because the symptoms often mimic those of other diseases. However, if you know what to look out for, it can be easy to pinpoint the symptoms and make lifestyle changes to maximize the health and efficiency of the liver.

Here are some of the most common symptoms associated with the liver:

  • Abdominal pain and swelling
  • Swelling in the legs and ankles
  • Itchy skin
  • Dark urine color
  • Pale stool color
  • Chronic fatigue
  • Nausea or vomiting
  • Loss of appetite
  • Tendency to bruise easily

A good way to reduce the chances of feeling these symptoms is to take good care of your liver. This can be done through lifestyle changes and regular use of a good liver detox supplement.

Lifestyle changes

Everything that you consume, including medicines, passes through the liver. Therefore, it is critical to treat your liver right for it to stay healthy and do its job efficiently. Below are some of the most useful lifestyle changes that will help improve your liver health.

Start Eating Healthy

Maintaining a healthy weight can help prevent chances of you getting non-alcoholic fatty liver disease that can lead to cirrhosis. Providing your body with just the right amount of nutrition and avoiding junk food is the key here.

Limit Alcohol Intake

Alcohol can damage liver cells and lead to life-threatening conditions such as cirrhosis.

Quit Smoking

Besides protecting your liver, staying away from smoking can have a positive impact on all areas of your life.

Reduce Stress

Stress can have a detrimental effect on your liver on account of excessive cortisol secreted by the body in stressful circumstances.


Exercising reduces the risk of fat accumulation around the liver. Fatty liver can lead to inflammation, scarring, cirrhosis, or even liver cancer. 

Liver FAQ

What does the liver do in your body?

The liver helps metabolize medications and detoxifies chemicals. The liver also produces bile which helps with digestion, metabolizes bilirubin, helps with clotting factor production, metabolizes fats and carbohydrates, and it stores vitamins and minerals.

Can the liver regenerate?

The liver is the only visceral organ that can grow back if it is damaged or part of it is removed. As long as at least 25% of the tissue remains, the liver can regenerate back to its original size in just weeks.

Can heavy alcohol use damage the liver?

Absolutely! Limiting your alcohol usage is essential if you want to maintain a healthy liver for as long as you live.

Is the liver the largest organ in the body?

Yes. The liver is the largest solid organ in the body. 

Do liver detox supplements work?

A carefully formulated product can work wonders. Please do your research and avoid dubious brands that can make matters worse. Refer to the brand reviews above for a curated list of reliable brands.


The cost of maintaining optimal liver health is relatively low. But the cost of neglecting your liver health can be heavy and even detrimental to your health in the long run.

It’s essential to do your research and pick a liver detox product that suits your needs. These are the best liver health detox products available on the market today:

Top Pick: Oweli Liver Detox

Reliable Choice: Clinical Effects Liver Support

Cost-effective: Organifi Liver Reset

Accessible: 1MD LiverMD

Decent choice: Amy Myers MD Liver Support

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